Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team
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For severe deficiency, patients get 1,000 mcg daily for the first week
Vitamin B6: Functions: It improves brain development, certain functions of the immune system, and red blood cell production
The most common dose for treating deficiency is 1,000 mcg
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